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. 2017 Mar 6;8(4):384–389. doi: 10.1021/acsmedchemlett.6b00423

Figure 4.

Figure 4

Inhibitory effect of compound 27 against LSD1 in MGC-803 cells. (A) High content analysis of the LSD1 inactivation status at indicated concentration using H3K4me2 as an indicator. (B) High content analysis of LSD1 expression with indicated treatment. (C) Western blot analysis of different histone modifications at indicated concentration. (D) Relative mRNA level of CD86 in MGC-803 cells with 4 μM compound 27 treatment. Data are mean ± SD. *p < 0.05 was considered significant; **p < 0.01 was considered statistically significant. All experiments were carried out at least three times.