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. 2017 Mar 6;8(4):384–389. doi: 10.1021/acsmedchemlett.6b00423

Figure 6.

Figure 6

Binding modes of compounds 18 and 20 in the active site of LSD1/CoREST complex (PDB: 2V1D). For clarity, only key residues (in gray) in the active site of LSD1 are shown, together with the cofactor FAD (light blue stick model). Compounds 18 and 20 are highlighted in brown tube model, and hydrogen bonds are shown as green dashed lines. (A,B) Three- and two-dimensional binding modes of compound 20 in LSD1 active site. (C,D) Three- and two-dimensional binding modes of compound 18 in LSD1 active site.