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Comparison of ONX 0914 (orange) and 10 (green) within the human LMP7 and LMP2 structures (van der Waals surfaces). (a) In LMP7, a hydrophobic interaction between the p-methoxyphenyl group and C48 is a critical selectivity-driver for ONX 0914. (b) The LMP2 S2 pocket is more polar due to the C48S substitution. Replacement of the p-methoxyphenyl group on the ligand with less lipophilic functionality is well-tolerated.
