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. 2017 Mar 9;8(4):413–417. doi: 10.1021/acsmedchemlett.6b00496

Table 2. Mouse Pharmacodynamic Data for ONX 0914, 10, and 12a.

    analogue
ONX 0914 10 12
% activity remaining in blood relative to controla LMP2 95.0 ± 10.6 83.0 ± 4.2 31.1 ± 6.3
LMP7 65.3 ± 0.4 98.3 ± 2.5 102.5 ± 11.3
β5 99.8 ± 2.3 90.7 ± 3.9 101.7 ± 13.2
a

Nominal doses: ONX 0914 = 1 mg/kg, 10 = 2 mg/kg, 12 = 1 mg/kg. Data are reported as the mean ± SD (n ≥ 3 animals).