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| analogue |
||||
|---|---|---|---|---|
| ONX 0914 | 10 | 12 | ||
| cytokine IC50 (μM)a | IL-12/23 p40 | 0.12 ± 0.07 | >5.6 | >9.7 |
| TNF-α | 0.56 ± 0.25 | >25 | >25 | |
| IL-6 | 0.24 ± 0.06 | >15.8 | >19.2 | |
| GMCSF | 0.22 ± 0.14 | >25 | >25 | |
| IL-8 | 1.11 ± 0.81 | >25 | >25 | |
| IL-1b | 1.47 ± 0.73 | >25 | >25 | |
| viability IC50 (μM)a,b | 3.4 ± 1.7 | >25 | >25 | |
Data are reported as the mean ± SD (n = 4).
Viability IC50 was measured using CellTiter-Glo.
