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Hit compound identified from a phenotypic screen of apoptosis inhibition can block mitochondrial release of cytochrome c after Dox induced apoptosis. (a) (a) Structure and apoptosis inhibition activity of the hit compound, and the side groups (R1, R2, and R3) targeted in SAR development. (b) Immunofluorescence imaging of cytochrome c after treatment with the indicated compounds. The arrow on the middle column indicated an example of cytochrome c release. Scale bar: 20 μm.
