Figure 3.

Compound 33 (a) and compound 42 (b) have protective effects against ischemia-reperfusion injury. (left) Representative 2,3,5-triphenyltetrazolium chloride (TTC) stained sections from middle cerebral artery occlusion (MCAO) brains injected with 5 μL of the indicated concentrations of compounds 33 and 42. The white color represents the infarct, and the red color represents the normal tissue. (right) Quantification of relative infarct volume. The numbers 1–7 on the x-axis correspond to the treatments in the top panel. Bars represent means ± standard deviation, n = 3–6. P values are based on comparisons of each sample to the DMSO-treated ischemia-reperfusion (+) group. *: P, 0.05; **: P < 0.01; ***: P < 0.001.