Scheme 2. Radiosynthesis of [18F]APP-1.
Reagent and conditions: (d) potassium [18F]fluoride, Kryptofix 2.2.2, MeCN, 90 °C, 5 min; and (e) Et3N, DMF, 110 °C, 20 min, 3.2 ± 0.94% radiochemical yield (n = 5, EOS from potassium [18F]fluoride).
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