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. 2017 Mar 20;8(4):418–422. doi: 10.1021/acsmedchemlett.6b00520

Table 1. IC50 for APP-1, Erlotinib, and AZD9291.

  IC50a (nM)
compd L858R L858R/T790M
APP-1 15.6 ± 0.8 326 ± 64
Erlotinib 12.5 ± 6.0 4040 ± 1270
AZD9291 12.3 ± 3.1 14.5 ± 5.3
a

The values represent the mean ± SE (n = 3).