Table 1.

Meta-analyses showing benefits of antibiotic treatment in acute pancreatitis

Study	Year	Study type	Studies (n)	Patients		Pancreatitisa	Significant reduction with antibiotics
				Total(n)	Controls(n)		All-cause mortality	Infection/pancreatic necrosis
Ukai et al20	2015	RCT	6	397	195	NP	Yes	Yes
Lim et al21	2015	RCT (9) Cohort (2)	11	864	413	NP	All studies: Yes RCT alone: No Cohort alone: Yes	No
Jiang et al31	2012	RCT	11b	183 (< 2000) 439 (> 2000)	95 219	SAP	Yes < 2000 No > 2000	–
Wittau et al32	2011	RCT	14	841	421	SAP	No	No
Bai et al33	2010	RCT	9	519	256	NP	No	No
Yao et al25	2010	RCT	9	564	277	NP	No	Yes
Villatoro et al27	2010	RCT	7	404	201	NP	No	No
Jafri et al30	2009	RCT	8	502	249	SAP	No	No
Hart et al34	2008	RCT	7	429		NP	No	No
Bai et al38	2008	RCT	7	467	231	NP	No	No
Xu et al26	2008	RCT	8	540	270	NP	No	Yes
Dambrauskas et al18	2007	RCT	10	1,279	638	NP	Yes	Yes
De Vries et al35	2007	RCT	6	397	194	SAP	No	No
Mazaki et al36	2006	RCT	6	329	162	NP	No	No
Xiong et al37	2006	RCT	6	338	165	SAP	No	No
Villatoro et al22	2006	RCT	5	294		NP	Yes	No
Sharma et al23	2001	RCT	3	160	76	NP	Yes	No
Golub et al24	1998	RCT	8	514	255	SAP	Yes	–

NP, necrotising pancreatitis; RCT, randomised controlled trial; SAP, severe acute pancreatitis

^a All patients with SAP/NP alone.

^b 4 up to year 2000, 7 after 2000 (no studies in year 2000 itself)