Table 4.
Performance of DHCR7 rs12785878 polymorphism, liver fibrosis, and rapid virologic response for predicting sustained virologic response in hepatitis C virus genotype 1-infected patients
| Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|
| DHCR7 rs12785878 GG/TT | 37% | 76.6% | 59.7% | 56.6% |
| Liver fibrosis stage 0–1 | 81% | 47.6% | 66% | 66.7% |
| RVR | 64.9% | 68.6% | 69.8% | 63.6% |
| DHCR7 rs12785878 GT/TT and RVR | 18.1% | 95.9% | 81% | 54.7% |
| DHCR7 rs12785878 GT/TT and liver fibrosis stage 0–1 | 18.4% | 97.9% | 88.9% | 57.2% |
PPV positive predictive value, NPV negative predictive value, RVR rapid virologic response