Table 2.
Genes with Variants in H37Ra Unique to our Assembly
| Locus Tag | Gene name | Variant | Notes |
|---|---|---|---|
| Rv0279ca, b | PE_PGRS4 | Two substitutions | Both mutations are not specific to H37Ra |
| Rv0383ca, b | Rv0383c | A459399C - 84bp upstream of Rv0383c | Potential sequencing error in H37Rv [8] |
| Rv1450ca, b | PE_PGRS27 | 208bp inframe insertion | |
| Rv1764 | Rv1764 | insertion of IS6110 | |
| Rv3303ca, b | lpdA | 174bp insertion 12bp upstream | Tandem repeat CNV |
| Rv3343ca | PPE54 | 1728bp insertion | Tandem duplication with respect to H37Rv |
| Rv3508a | PE_PGRS54 | multiple variants | |
| Rv3514b | PE_PGRS57 | multiple variants | Only two are H37Ra-specific |
The mutations in this table are with respect to the H37Rv reference (NC_000962.3), so variants with respect to the current H37Ra reference sequence (NC_009525.1) that cause agreement with the H37Rv sequence do not appear here.
agene previously implicated as affected by H37Ra-specific mutations [5].
bone or more mutations affecting this gene are also present in at least one of the sequences CDC1551 (NC_002755.2), H37RvBroad (NC_018143.2), H37RvSiena (NZ_CP007027.1), and H37RvTMC102 (NZ_CP009480.1)