Table 3.

Detailed clinical features of patients with progressive supranuclear palsy

Patient	Age at onset (years)	Age at death (years)	NINDS-SPSP criteria during life	Frontal presentation	Family history	Relevant medication in the last 3 months of life	Brain weight (g)	Tau pathology area 24'	Tau pathology caudate
1a	71	73	Probable	Nonfrontal	Negative	Clonazepam, temazepam, piracetam	1398	Grade 3	Grade 2
2	66	76	Probable	Frontal	Negative	Oxybutynin, acetylcysteine, thiopental, pancuronium	1060	Grade 3	Grade 2
3	63	68	Probable	Nonfrontal	Positive	Temazepam, oxybutynin	1405	Grade 3	Grade 4
4	70	79	Possible	Frontal	Positive	Tolterodine	1069	Grade 2	Grade 2
5	51	60	Probable	Frontal	Negative	Temazepam	1256	Grade 3	Grade 4
6a	74	80	Possible	Nonfrontal	Negative	Thiopental, pancuronium	1100	Grade 2	Grade 1
7	66	75	Possible	Frontal	Negative	Levomeprazine	1253	Grade 3	Grade 1
8	54	64	Possible	Frontal	Positive	Amantadine	1290	Grade 3	Grade 1
9	79	85	Possible	Nonfrontal	Negative	Oxazepam, nitrazepam, acetylcysteine	1175	Grade 2	Grade 2
10	68	79	Probable	Nonfrontal	Negative	Amitriptyline	922	Grade 2	Grade 1
11	60	72	Possible	Nonfrontal	Positive	Levodopa/carbidopa, amitriptyline	1045	Grade 2	Grade 2
12	60	67	Probable	Frontal	Positive	Levodopa/carbidopa, lormetazepam, nortriptyline	1013	Grade 4	Grade 2
13	62	70	Probable	Nonfrontal	Negative	Amantadine, temazepam, diazepam, amitriptyline	1160	Grade 2	Grade 3
14a	79	85	Possible	Nonfrontal	Negative	Alprazolam, tamsulosin, thiopental, pancuronium	1305	Grade 3	Grade 3
15	67	72	Possible	Nonfrontal	Positive	Levodopa/carbidopa	1525	Grade 2	Grade 4
16	61	69	Probable	Frontal	Positive	Midazolam, clozapine	1270	Grade 3	Grade 3

NINDS-SPSP National Institute of Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy

^aPatients who underwent euthanasia by sodium thiopental and pancuronium bromide