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. Author manuscript; available in PMC: 2017 Apr 17.
Published in final edited form as: Cell Rep. 2017 Mar 21;18(12):2932–2942. doi: 10.1016/j.celrep.2017.02.065

Figure 5. Overexpression of Ptpn11mut inhibits the developmentally-timed apoptotic response triggered by MYCN overexpression in the IRG.

Figure 5

(A) Sagittal sections through the IRG of MYCN (top panels) and MYCN;ptpn11mut (bottom panels) transgenic fish at 5.5 wpf (dorsal up, anterior left). GFP, green; activated caspase-3, red; DAPI, blue. Arrowheads point to the activated caspase-3+ apoptotic cells. Dotted lines indicate the head kidney (HK) boundary. Scale bars, 10 μm.

(B) Percentage of activated caspase-3+ apoptotic cells to the total number of GFP+ sympathetic neuroblasts in the IRG of MYCN and MYCN;ptpn11mut fish at 5.5 wpf. Mean values (horizontal bars) were compared by the Welch t-test (two-tailed).