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. 2017 Mar 1;31(5):463–480. doi: 10.1101/gad.290924.116

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© 2017 Filipescu et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 8. — Proposed model: HJURP sustains cellular transformation in cells lacking p53. HJURP and CENP-A levels are increased in cells that lose p53 expression and increase even further following oncogenic transformation. When HJURP is depleted in wild-type cells with functional p53, p53 senses gradual CENP-A depletion and induces cell cycle arrest in order to maintain genome integrity. In cells lacking p53, HJURP depletion results in rapid CENP-A loss at centrosomes, leading to centrosome dysfunction, aneuploidy, and p53-independant apoptosis.