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. 2017 Mar 1;31(5):524–535. doi: 10.1101/gad.294546.116

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© 2017 Isomura et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 3. — Entrainment of a population of genetic oscillators by periodic optogenetic perturbation. (A) Single-cell traces (gray) and traces of population average (red) in the presence of periodic perturbation at periodicities ranging from 2.0 to 5.0 h. Blue vertical lines represent timings of illumination of a 2-min duration. (B) Peak time distributions under the dark condition or perturbation at periodicities ranging from 1.83 to 6.0 h. N represents the number of analyzed peak events. (C) Synchronization index calculated by the entropy-based method.