Table 2. SUVs (mean ± SD) 1 hr after injection of peptide into mice.
Organ | Cleavable peptide | All-d-amino acid control peptide |
---|---|---|
Skin | 0.6 ± 0.4 | 0.2 ± 0.3 |
Muscle | 0.2† | 0.0† |
Brain | 0.2† | 0.1 ± 0.1 |
Intestine | 0.6 ± 0.3 | 0.4 ± 0.4 |
Liver | 1.2 ± 0.5 | 0.6 ± 0.1 |
Spleen | 0.2† | 0.0† |
Colon | 0.9 ± 0.3 | 0.7 ± 0.2 |
Lung | 0.1 ± 0.1 | 0.0 ± 0.1 |
Plasma | 1.4 ± 0.1 | 1.7 ± 0.2 |
Salivary | 0.4 ± 0.1 | 0.3 ± 0.1 |
Kidney | 5.3 ± 0.6 | 3.2 ± 0.9 |
Heart | 0.2 ± 0.1 | 0.0† |
Pancreas | 0.7 ± 0.2 | 0.2† |
Tumors (P < 0.05) | 1.3 ± 0.4 | 0.4 ± 0.3 |
The cleavable peptide was [11-kDa PEG]-X-e9-XPLG*LAG-r9-Xk(Cy5), and the uncleavable peptide was [11-kDa PEG]-X-e9-Xplglag-r9-Xk(Cy5).
Standard deviation was <0.05 in these samples.