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. 2017 Feb 16;26(8):1552–1564. doi: 10.1093/hmg/ddx059

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Validation of hypoxia-responsive miRNAs by qRT-PCR in six CRC cell lines. (A and B) Fold change expression of candidate miRNAs in normoxia (20.9%) and low oxygen tensions (1 and 0.2% oxygen) in six CRC cell lines combined. (C) Heatmap of fold change (log 2) in miRNA expression between the three oxygen conditions normalized to 20.9% oxygen (n = 3). (D) Multivariate analysis (linear regression model) identified a significant up-regulation of 6 of the 12 miRNAs between in hypoxia. The heatmap is ranked according to P-values obtained from the multivariate analysis. Asterisks indicate significantly altered (P < 0.05) miRNAs. Bars represent mean values with SEM calculated from three individual experiments. *P < 0.05, **P < 0.01 and ***P < 0.001.