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. 2017 Feb 16;26(8):1552–1564. doi: 10.1093/hmg/ddx059

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cellular metabolism altered under hypoxic conditions in CRC cell lines. Metabolite analysis via CE-TOF/MS between six CRC cell lines maintained under normoxic (20.9%) and low oxygen conditions (1 and 0.2%). Over-representation analysis of significantly altered metabolites was performed using MetaboAnalyst. (A) Ten significant pathways associated with altered metabolites under hypoxic conditions. (B–E) In silico analysis of miRNA target prediction of genes involved in the ten pathways. Four pathways showed a significant association between hypoxia-responsive miRNAs. Genes with a miRSVR score lower than -1.25 are listed.