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. 2017 Feb 16;26(8):1552–1564. doi: 10.1093/hmg/ddx059

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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MiRNA expression profiling in 5FU resistant CRC tumours and modulation of resistance in hypoxic DLD-1 cells. Eleven CRC tumours treated with 5-FU treatment (six non-responders, five responders) were subjected to miRNA profiling. (A) Heatmap of significant altered miRNAs (P < 0.05, Benjamini-Hochberg adjusted). Corrected P-values are shown. (B) Fold change in expression of miRNAs significantly altered between each group. (C and D) Correlation between patient survival and expression of miR-21 or miR-30d. Spearman’s rank analysis indicated a significant correlation between each miRNA and patient survival.