Fasting and post-challenge dysglycemia in PCOS. The individual fasting and 2-h post-75 g oral glucose challenge glucose data from 254 women with PCOS are shown. The dotted vertical line is the fasting glucose threshold for impaired fasting glucose (100 mg/dl), the dashed vertical line is the fasting glucose threshold for diabetes (T2D) (126 mg/dl), the dotted horizontal line is the post-challenge glucose threshold for IGT (140 mg/dl), and the horizontal dashed line is the post-challenge glucose threshold (200 mg/dl) for T2D, according to the American Diabetes Association criteria (158). Most women with PCOS have post-challenge rather than fasting dysglycemia. NGT, Normal glucose tolerance. [Adapted from R. S. Legro et al.: Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84:165–169, 1999 (123), with permission. © The Endocrine Society.]