Table 4.

Members of TGFβ signaling family

Ligands

Inhibins, activins, myostatin, BMPs, GDFs, AMH, TGFβ1-3, nodal

Extracellular antagonists

Follistatin, follistatin-like 3, fibrillins, noggin, chordin, DAN/cereberus

Type I receptors

ACVR1, ACVR1B, ACVR1C, BMPR1A, BMPR1B, TGFβR1

Type II receptors

ACVRL1, ACVR2A, ACVR2B, BMPR2, AMHR2, TGFβR2

Type III receptors

TGFβR3, ENG, IgSF

Intracellular modulators of signaling

Smad1-8, Smurf1-2, SARA, TRAP1, BAMBI, Gsc

ACVRs, Activin receptors; ACVRL1, activin A receptor type II-like 1; AMH, anti-Mullerian hormone; BAMBI, BMP and activin membrane-bound inhibitor homolog; BMPs, bone morphogenic proteins; DAN, differential screening-selected gene aberrative in neuroblastoma; ENG, endoglin; Gsc, goosecoid; GDFs, growth differentiation factors; IgSF, Ig superfamily; SARA, Smad anchor for receptor activation; Smads, Mothers against decapentaplegic homolog; R, receptor; TRAP-1, TGFβ receptor associated protein-1.