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A review of the Comprehensive Medicinal Chemistry database shows that, of more than 7000 small-molecule drugs, only 5% treat the CNS, and these drugs only treat four disorders: depression, schizophrenia, chronic pain, and epilepsy.6,7 There are few effective small- or large-molecule drugs for the majority of CNS disorders, with the exception of Parkinson’s disease, e.g., l-DOPA, and multiple sclerosis, e.g., cytokines.
