FIG. 12.

Fasting-induced alterations in BBB GLUT1 expression are in the opposite direction to the alterations in pericapillary glial end-foot MCT2 expression. As shown before, increased GLUT1 expression was seen. We observed this in the (frontal cortex, hippocampus, not shown, and) superior colliculus. Furthermore, overnight fasting decreased astrocyte monocarboxylic acid transporter (MCT2) expression in mice. Pericapillary and brain parenchymal MCT2 expression was reduced in fasted mice (right panel), whereas GLUT1 is upregulated (left panel). (Vertical bars = 1 SD.)