FIG. 6.

Caveolin-1 expression in the BBB endothelial cell from a human seizure resection. The rabbit polyclonal antiserum to caveolin-1 was obtained from Santa Cruz Biotechnology Inc. (Santa Cruz, CA) and was used at a dilution of 1:100. Caveolins are known to participate in the formation of cytoplasmic vesicular structures, and transcytosis mechanisms. They may therefore assume an important role in facilitating the BBB transport of molecular Trojan horses that piggy-back large molecules via receptor transcytosis. This protein appears to have a predominant expression at the endothelial cell membranes and to a lesser extent within the cytoplasmic domain.