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PLP and GABA bound to the truncated Eb/O domain. (A) Simulated annealing omit map (Fo-Fc) is shown around the PLP-GABA Schiff base at 3σ. (B) Eb/O–PLP–GABA complex in comparison to GABA-AT with AOA bound to PLP mimicking the PLP-GABA external aldimine (green, PDB ID code 1SFF).