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. 2017 Mar 27;114(15):3999–4004. doi: 10.1073/pnas.1616874114

Fig. 3.

Fig. 3.

BRF110 protects DAergic neurons against MPTP toxicity. (A) Improved rotarod test performance of C57BL/6 mice exposed to MPTP and receiving BRF110 treatment for 7 d. (B) Stereological counting of SN TH(+) neurons (average/side) in control C57BL/6 mice and mice exposed to MPTP and receiving either vehicle or BRF110 treatment. (C) Images of TH immunohistochemistry (IHC) in the SN of control C57BL/6 mice and mice exposed to MPTP and receiving either vehicle or BRF110 treatment. (D) Images of TH IHC of SN DAergic projections to the striatum in C57BL/6 mice exposed to MPTP and receiving either vehicle or BRF110 treatment. (E) Quantitation of TH IHC DAergic projections to the striatum of C57BL/6 mice exposed to MPTP and receiving either vehicle or BRF110 treatment. (F) Stereological counting of SN TH(+) neurons of control WT 129SV mice and mice exposed to MPTP and receiving either vehicle or BRF110 treatment (average/side) (first three bars) and of Nurr1+/− 129SV mice exposed to MPTP and receiving either vehicle or BRF110 treatment (last three bars).