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Pharmacokinetics of XCT0135908. Intraperitoneal administration of XCT0135908 in mice (1 mg/kg) resulted in minimal penetration of the compound in the brain. Three serial tail bleeds were performed to detect the compound in plasma at 1 and 2 h after i.p. administration. Similarly, mice (n = 3) were killed at 1 and 2 h after i.p. administration, and brains were dissected. The concentrations of the parent compound in plasma and brain were determined by LC-MS/MS.
