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Schematic diagram illustrating the changes induced in cell function by phosphomimetic Y48pCMF Cc. The negative charge at position 48 decreases CcO activity by disrupting Cc channeling in OxPhos supercomplexes (Left), enhances ROS scavenger activity by increasing the peroxidase activity of CL-bound Cc (Middle), and promotes the antiapoptotic function of Y48pCMF Cc by inhibiting its ability to activate the caspase-3 cascade (Right).
