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. 2017 Mar 28;114(15):E3101–E3109. doi: 10.1073/pnas.1700759114

Fig. 4.

Fig. 4.

Comparison of the mutational patterns of human liver cancer with the murine AFB1 exposure spectrum. (A) Dendrogram showing the results of unsupervised clustering of 314 human HCCs and murine spectrum A-10. The red cluster indicates the 13 human HCC samples with closest cosine similarity to A-10 (the blue vertical stripe). (B) HRMS of A-10 and the mutational spectra of the five human HCCs most similar to A-10 identified in A. The yellow stripe highlights the G:C→T:A hotspot in the 5′-CGC-3′ context. All five humans harbored TP53 mutations, and four specifically carried the TP53.R249S mutation. (C) Cosine similarity matrix of the red cluster from A with the murine spectrum A-10. The numbers in the matrix (also the darkness of the shade of blue) indicate the cosine similarity between compared samples. Asterisks on the bottom of the matrix indicate TP53 status (*known mutation in TP53, but not at position 249; **TP53.R249S mutation; no asterisk indicates TP53 wild type or status unknown).