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The 6-thioguanine–selected mutational spectrum of AFB1 in the gpt coding sequence of the λ-gptΔ B6C3F1 mouse. The spectrum was generated from the data of Woo et al. (16) plotted in three-base contexts as done in the present paper (e.g., Fig. 3A). Mice were treated with 6 mg/kg AFB1 at day 4 of life and killed at 10 wk for mutation analysis by a protocol that selected for mutants that confer resistance to 6-thioguanine. A total of 131 mutants are plotted.
