Fig. S7.

Correlation of coverage score for DNase-based and restriction enzyme-based Hi-C experiments. (A) Correlation of two biological replicates of DNase-based Hi-C for GAL1pr-FKH1 fkh2∆ cells. (B) Correlation of DNase-based Hi-C for asynchronous WT cells and restriction enzyme-based Hi-C for asynchronous WT cells. (C) Correlation of DNase-based Hi-C for asynchronous WT cells and restriction enzyme-based Hi-C for G1 arrested WT cells. (D–F) The difference in interaction frequency in WT and Fkh1/2-depleted cells as a function of Fkh1/2 binding site density (D), Swi4 binding site density (E), and gene density (F). Interaction frequency likely correlates with general transcriptional activity.