Fig. S8.

Replication timing correlation with TAD organization is not because of centromeric effects. (A) Difference in origin–origin interaction frequency from WT to Fkh1/2-depleted cells (as in Fig. 6C) assessed without including interactions with bins containing a centromere. The pattern of change in interaction frequency is not a result of interactions with bins containing the centromeres. (B) Mean replication timing differences and associated SE for ARS loci within and across domains was analyzed as in Fig. 4C after excluding all domains containing centromeres. Origins within domains activate at more similar times than those in neighboring domains.