Fig. 8.

GLP-1 secretion in MKR mice, a nonobese model of chronic hyperinsulinemia. A, Age- and sex-matched MKR mice and wild-type FVB mice were analyzed for body weights at 11 wk of age (n = 31–36/group). **, P < 0.01. B, After a 3-h fast, insulin sensitivity of MKR (black squares, n = 9) and FVB (white circles, n = 14) mice were assessed by ip insulin tolerance test (n = 9–14). *, P < 0.05; ***, P < 0.001. C–E, Mice were fasted overnight and administered an oral glucose tolerance test (6 g/kg). Blood glucose (C), plasma insulin (D), and plasma bioactive GLP-1 (E) levels were determined at t = 0 min and 10 min after oral glucose administration (n = 14–17/group). *, P < 0.05; **, P < 0.01; ***, P < 0.001. OGTT, Oral glucose tolerance test.