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. 2005 Jan;2(1):108–119. doi: 10.1602/neurorx.2.1.108

TABLE 1.

Ideal Properties of Nanoparticles for Drug Brain Delivery

  • Nontoxic, biodegradable, and biocompatible

  • Particle diameter < 100 nm

  • Physical stability in blood (no aggregation)

  • Avoidance of the MPS (no opsonization), prolonged blood circulation time

  • BBB-targeted and brain delivery (receptor-mediated transcytosis across brain capillary endothelial cells)

  • Scalable and cost-effective manufacturing process

  • Amenable to small molecules, peptides, proteins, or nucleic acids

  • Minimal nanoparticle excipient-induced drug alteration (chemical degradation/alteration, protein denaturation)

  • Possible modulation of drug release profiles