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. 2014 Apr 15;155(7):2613–2623. doi: 10.1210/en.2014-1101

Figure 3.

Figure 3.

Estradiol increases amplitude through ESR1 and delays acrophase of wheel running activity via ESR2. A, Acrophase of wheel running activity averaged over 3 days in LD across CTL, LowE, HighE, LowPPT, HighPPT, LowDPN, and HighDPN OVX female mice. Plotted between ZT12 and ZT18 (mean ± S.E.M.), the sample sizes per group are as follows: CTL (n = 10), LowE (n = 10), HighE (n = 11), LowPPT (n = 8), HighPPT (n = 8), LowDPN (n = 8), and HighDPN (n = 9). ♦♦, P < .001 compared with CTL. B, Amplitude plotted as the difference between the daily wheel running peak and mesor. Values represent the mean ± SEM. The number of mice (n) per treatment is shown below the corresponding bar. ♦, ○, ●, and ✚ denote significant comparisons made with CTL, LowE, HighE, and HighPPT, respectively; 1 symbol, P < .05; 2 symbols, P < .001. C, Polargram representation of the effects of estradiol, PPT, and DPN administration on acrophase of wheel running activity and amplitude. The radial axis value intersected by a given treatment group's vector corresponds to the acrophase of wheel running activity. Both degrees and ZT are shown. Vector length is indicative of amplitude magnitude. Variance is shown in A and B.