Table 3.
Bone microarchitecture and bone formation in 3-month-old WT, Ghsr−/−, ob/ob, and ob/ob.Ghsr−/− mice
| WT | Ghsr−/− | P | ob/ob | P | ob/ob.Ghsr−/− | P | |
|---|---|---|---|---|---|---|---|
| Cortical bone | |||||||
| Ct.Th (μm) | 261 (6.48) | 253 (10.5) | ns | 210 (9.56) | b | 211 (4.63) | c |
| Ec.V (mm3) | 1.52 (0.04) | 1.63 (0.07) | ns | 1.63 (0.04) | ns | 1.70 (0.07) | ns |
| Perimeter (mm) | 6.15 (0.20) | 6.14 (0.23) | ns | 5.18 (0.27) | a | 5.23 (0.19) | a |
| Trabecular bone | |||||||
| Tb.Th (μm) | 81.9 (2.01) | 80.0 (4.40) | ns | 61.8 (0.63) | c | 64.7 (1.27) | c |
| Conn.D (mm−3) | 146 (12.3) | 118 (7.52) | ns | 185 (23.9) | ns | 139 (4.8) | ns |
| Bone formation | |||||||
| P1NP (ng/ml) | 101 (18.6) | 94.6 (14.0) | ns | 60.5 (6.92) | b | 44.8 (7.38) | c |
Data are shown as average (sem). ns, Not significant.
a
P < 0.05 vs. WT.
b
P < 0.01 vs. WT.
c
P < 0.001 vs. WT.