Table 4.
Bone microarchitecture and bone formation in 6-month-old WT, Ghsr−/−, ob/ob, and ob/ob.Ghsr−/− mice
| WT | Ghsr−/− | P | ob/ob | P | ob/ob.Ghsr−/− | P | |
|---|---|---|---|---|---|---|---|
| Cortical bone | |||||||
| Ct.Th (μm) | 233 (4.49) | 243 (3.90) | ns | 232 (2.88) | ns | 232 (6.31) | ns |
| Ec.V (mm3) | 1.61 (0.06) | 1.34 (0.06) | a | 1.59 (0.06) | ns | 1.68 (0.1) | d |
| Perimeter (mm) | 6.70 (0.13) | 6.03 (0.13) | b | 6.11 (0.17) | a | 6.00 (0.22) | a |
| Trabecular bone | |||||||
| Tb.Th (μm) | 74.1 (1.67) | 68.7 (2.47) | ns | 66.6 (0.86) | b | 66.4 (0.73) | c |
| Conn.D (mm−3) | 56.8 (5.52) | 18.8 (4.88) | b | 128 (16.68) | b | 71.4 (6.43) | ns |
| Bone formation | |||||||
| P1NP (ng/ml) | 49.3 (2.84) | 43.9 (6.11) | ns | 67.6 (30.4) | ns | 42.43 (0.76) | ns |
Data are shown as average (sem). ns, Not significant.
a
P < 0.05 vs. WT.
b
P < 0.01 vs. WT.
c
P < 0.001 vs. WT.
d
P < 0.05 for interaction.