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. 2005 Jan;2(1):139–150. doi: 10.1602/neurorx.2.1.139

FIG. 3.

FIG. 3.

A: Coronal section of autopsy rat brain at 14 days after implantation of C6-790 rat glioma cells in the caudate-putamen of adult Fischer CD344 rats (180-200 g). The C6 cells were permanently transfected with clone 790 plasmid DNA, and produce high levels of luciferase when grown as brain tumors in vivo.44 B: Luciferase activity in brain tumor and contralateral brain of controls (saline injected) and shRNA-952 TfR mAb-PIL treated rats. At 10 days after C6-790 tumor implantation, the rats were intravenously injected with either saline or 10 μg/rat of clone 952 plasmid DNA encapsulated in PILs conjugated with the OX26 TfR mAb to target delivery through the BBB and gene delivery to brain tumor cells. Animals were sacrificed 2 days later and luciferase activity quantified. C: GTP activity in brain cancer and contralateral brain showing that PIL treatment does not alter the expression pattern of this maker. Data are mean ± SEM (n = 4-5 rats per point). Reproduced with permission44 (see FIG. 2 legend).