FIG. 8.

Survival study. Intravenous RNAi gene therapy directed at the human EGFR is initiated at 5 days after implantation of 500,000 U87 cells in the caudate putamen nucleus of scid mice, and weekly intravenous gene therapy is repeated at days 12, 19, and 26 (arrows). The control group was treated with saline on the same days. There are 11 mice in each of the two treatment groups. The time at which 50% of the mice were dead (ED₅₀) is 17 days and 32 days in the saline and RNAi groups, respectively. The RNAi gene therapy produces an 88% increase in survival time, which is significant at the p < 0.005 level (Fisher’s exact test). Reproduced with permission⁴¹ (see Table 1 legend).