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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Neurobiol Aging. 2017 Feb 7;53:122–137. doi: 10.1016/j.neurobiolaging.2017.01.023

Table 1.

Experimental design

Experiment Group size Chemical classes tested Olfactory discrimination Olfactory detection threshold Water maze
Experiment 1 n = 8 (6 mo at start) Alcohols
Δ5, Δ3, Δ1		 Longitudinal testing, stimuli repeated Not assessed Not assessed
Experiment 2
(cohort A)		 n = 4, 6 mo
n = 6, 24 mo		 Alcohols
Δ5, Δ3, Δ1		 Single test, stimuli used only once Three alcohols and 1 unrelated odorant After olfactory testing
Experiment 2
(cohort B)		 n = 8, 6 mo
n = 8, 24 mo		 Alcohols
Δ5, Δ3, Δ1
Aldehydes
Δ5, Δ3, Δ1
Acids
Δ5, Δ3, Δ1
Unrelated odorants		 Single test, stimuli used only once One odorant in each chemical class and 1 unrelated odorant Before olfactory testing