Table 1.

Structures, pharmacological class, mechanism, relative selectivity for monoamine transporters as inhibitors and substrates, and interpolated ED₅₀ values for cocaine-like discriminative stimulus effects. Dashes indicate no pharmacologically-relevant effects for the given endpoint.

Test compound	Structure	Drug class	Mechanism	Inhibition selectivity	Monoamine release	ED50 (±95% CI)
(−)-cocaine		Stimulant	Blocker	DAT ≈ NET ≈ SERT	—	3.0 mg/kg (0.9, 5.2)
METH		Stimulant	Releaser	NET > DAT > SERT	DA > 5-HT	0.4 mg/kg (0.3, 0.6)
MDMA		Stimulant	Releaser	NET ≈ SERT ≈ DAT	DA ≈ 5-HT	2.6 mg/kg (0.8, 4.3)
Mephedrone		Stimulant	Releaser	NET > DAT ≈ SERT	DA ≈ 5-HT	1.5 mg/kg (1.1, 2.0)
Naphyrone		Stimulant	Blocker	NET ≈ DAT ≈ SERT	—	3.2 mg/kg (1.3, 5.0)
Morphine		Opioid	μ agonist	—	—	—