Fig. 2.

Changes in host proteome over the time course of HSV-1 infection. A, Schematic of different phases during the HSV-1 infection cycle. Representative cluster trends showing changes in abundance of proteins involved in the different stages of virus infection are displayed in boxes. For example, proteins involved in viral transcription are activated at 3 hpi, whereas proteins responsible for viral transport or release of new virions increase in abundance at early (3–6 hpi) and late time points (15 hpi). B, Heatmap of GO biological process enrichment of host proteins detected in 16 independent clusters (all displayed in supplemental Fig. S3).