Table I. Staphylococcus aureus virulence factors grouped based on functional classes with UniProt identifier, common protein names, USA300 gene identifiers, and common protein names. These proteins represent three major classes of virulence factors which are highlighted in this study to understand cytotoxicity and other virulence behaviors.

Protein class	Protein function	Uniprot accession	Common protein ID	USA300 gene ID	Protein name
Immunomodulators	Bind to IgG and prevent opsonization	A0A0H2XJH7	SPA	SAUSA300_0113	Immunoglobulin G binding protein A
	Bind to IgG and prevent opsonization	Q2FE79	SBI	SAUSA300_2364	Immunoglobulin-binding protein sbi
	Inhibit chemotaxis of phagocytes	Q2FHS7	FLR	SAUSA300_1053	FPRL1 inhibitory protein
	Inhibit chemotaxis of phagocytes	A0A0H2XIW0	EAP	SAUSA300_0883	Putative surface protein
	Complement inactivation/Fibrinogen-binding proteins	A0A0H2XG16	CLFA	SAUSA300_0772	Clumping factor A
	Complement inactivation	Q2FJ77	SDRE	SAUSA300_0548	Serine-aspartate repeat-containing protein E
	Complement inactivation	Q2FG07	ISDH	SAUSA300_1677	Iron-regulated surface determinant protein H
	Complement inactivation/Fibrinogen-binding proteins	A0A0H2XH00	ECB	SAUSA300_1052	Fibrinogen-binding protein
	Complement inactivation/Fibrinogen-binding proteins	A0A0H2XIH9	EFB	SAUSA300_1055	Fibrinogen-binding protein
	Complement inactivation	A0A0H2XFS8	SAK	SAUSA300_1922	Staphylokinase
	Fibrinogen-binding proteins/Surface-bound adhesins	Q2FE03	FNBA	SAUSA300_2441	Fibronectin-binding protein A
	Fibrinogen-binding proteins/Surface-bound adhesins	A0A0H2XKG3	FNBB	SAUSA300_2440	Fibronectin binding protein B
	Surface-bound adhesins	A0A0H2XHK2	CLFB	SAUSA300_2565	Clumping factor B
	Surface-bound adhesins	Q2FJ78	SDRD	SAUSA300_0547	Serine-aspartate repeat-containing protein D
Exo-enzymes	Protease	Q2FFS9	SPLF	SAUSA300_1753	Serine protease SplF
	Protease	Q2FFT0	SPLE	SAUSA300_1754	Serine protease SplE
	Protease	Q2FFT3	SPLD	SAUSA300_1755	Serine protease SplD
	Protease	Q2FFT1	SPLC	SAUSA300_1756	Serine protease SplC
	Protease	Q2FFT2	SPLB	SAUSA300_1757	Serine protease SplB
	Protease	Q2FFT4	SPLA	SAUSA300_1758	Serine protease SplA
	Protease	A0A0H2XGH9	SSPB	SAUSA300_0950	Cysteine protease
	Protease	A0A0H2XDQ5	AUR	SAUSA300_2572	Zinc metalloproteinase aureolysin
	Lipase	A0A0H2XK15	PLC	SAUSA300_0099	1-phosphatidylinositol phosphodiesterase
	Lipase	A0A0H2XI72	GEH	SAUSA300_0320	Triacylglycerol lipase
	Hyaluronidase	A0A0H2XIY1	HYSA	SAUSA300_2161	Hyaluronate lyase
	Nuclease	A0A0H2XHI2	NUC	SAUSA300_0776	Thermonuclease
	Coagulase	A0A0H2XHP9	COA	SAUSA300_0224	Staphylocoagulase
	Coagulase	A0A0H2XEN7	VWBP	SAUSA300_0773	Putative staphylocoagulase
Cytotoxins	Leukocidins	Q2FFA2	LUKA	SAUSA300_1975	Uncharacterized leukocidin-like protein 2
	Leukocidins	A0A0H2XI46	LUKS-PV	SAUSA300_1382	Panton-Valentine leukocidin, LukS-PV
	Leukocidins	A0A0H2XFK0	LUKF-PV	SAUSA300_1381	Panton-Valentine leukocidin, LukF-PV
	Leukocidins	Q2FFA3	LUKB	SAUSA300_1974	Uncharacterized leukocidin-like protein 1
	Leukocidins/hemolysins	A0A0H2XFN4	LUKD	SAUSA300_1768	Leukotoxin LukD
	Leukocidins/hemolysins	A0A0H2XJW6	LUKE	SAUSA300_1769	Leukotoxin LukE
	Leukocidins	P0C817	PSMA4	SAUSA300_0424.1	Phenol-soluble modulin alpha 1 peptide
	Leukocidins	P0C7Y0	PSMA2	SAUSA300_0424.4	Phenol-soluble modulin alpha 2 peptide
	Hemolysin	A0A0H2XEW5	HLA	SAUSA300_1058	Alpha-hemolysin
	Leukocidins/hemolysins	A0A0H2XIG9	hlgA	SAUSA300_2365	Gamma-hemolysin component A
	Leukocidins/hemolysins	A0A0H2XH48	HLGB	SAUSA300_2367	Gamma-hemolysin component B
	Leukocidins/hemolysins	A0A0H2XFL0	HLGC	SAUSA300_2366	Gamma-hemolysin component C