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Criteria used for the diagnosis of GHD in the study population (19)
| Diagnostic test | Diagnostic cut point | |
|---|---|---|
| Insulin tolerance test | Peak GH <3 ng/ml | |
| Glucagon stimulation test | Peak GH <3 ng/ml | |
| GHRH + arginine stimulation test | If BMI <25 kg/m2 | Peak GH <11.5 ng/ml |
| If BMI 25–30 kg/m2 | Peak GH <8 ng/ml | |
| If BMI >30 kg/m2 | Peak GH <4.2 ng/ml | |
| Arginine stimulation test | Peak GH <0.4 ng/ml | |
| IGF-I | IGF-I SDS <−2 and ≥ three additional pituitary hormone deficiencies | |
