Table 2.
Characteristics of the study population
| Variable | |
|---|---|
| Number (n) | 1218 |
| Age at diagnosis of pituitary disease (yr) | 40.7 (22.1, 59.6) |
| Age at diagnosis of GHD (yr) | 46.6 (28.2, 63.0) |
| Age at KIMS entry (yr) | 48.3 (31.2, 65.2) |
| Estimated GHD duration (yr) | 0.7 (0.0, 5.5) |
| Gender [females/males (%/%)] | 641/577 (53/47) |
| History of radiation therapy (n (%)) | 348 (28.6) |
| GH stimulation test | |
| Insulin tolerance test [n (%)] | 880 (72%) |
| All others [n (%)] | 338 (28%) |
| IGF-I SDS | −1.5 (−3.5, 0.1) |
| Gonadotropin deficiency [n (%)] | 948 (78) |
| Sex steroid substitution status (def/repl/suff) [n (%)] | 212/736/270 (17/61/22) |
| Corticotropin deficiency [n (%)] | 834 (68) |
| Thyrotropin deficiency [n (%)] | 870 (71) |
| Central diabetes insipidus [n (%)] | 286 (23) |
| History of fracture [n (%)] | 277 (23) |
| Fracture site [spine and pelvis/ribs/femur/lower extremity excluding femur/upper extremity (n (%)] | 20/23/14/70/147 (7.3/8.4/5.1/25.6/53.6) |
| LS sBMD (mg/cm2) | 1033 (847, 1285) |
| LS z score | −0.5 (−2.1, 1.5) |
| FN sBMD (mg/cm2) | 878 (691, 1066) |
| FN z score | −0.3 (−1.6, 1.2) |
Data are shown as number of patients, percentages, mean ± sd, or median (10th and 90th percentiles) as appropriate. def, Sex steroid deficient; repl, sex steroid replaced; suff, endogenously sex steroid sufficient.