Table 4.
Characteristics of the study population stratified by the presence or absence of corticotropin or thyrotropin deficiency
| Variable | Corticotropin deficiency vs. sufficiency |
Thyrotropin deficiency vs. sufficiency |
||||
|---|---|---|---|---|---|---|
| Def | Suff | P value | Def | Suff | P value | |
| Number (n) | 834 | 383 | 870 | 346 | ||
| Age at diagnosis of pituitary disease (yr) | 40.1 (22.3, 58.9) | 43.2 (21.3, 60.7) | NS | 40.4 (21.9, 59.1) | 41.4 (22.7, 60.5) | NS |
| Age at diagnosis of GHD (yr) | 46.8 (28.5, 63.7) | 46.4 (27.9, 62.4) | NS | 46.9 (28.3, 63.7) | 45.8 (27.9, 62.4) | NS |
| Age at KIMS entry (yr) | 48.8 (31.4, 65.7) | 47.6 (29.6, 64.2) | NS | 49.1 (31.5, 66.0) | 46.9 (29.1, 63.8) | <0.05 |
| Estimated GHD duration (yr) | 0.7 (0.0, 6.9) | 0.7 (0.0, 4.0) | NS | 0.7 (0.0, 7.1) | 0.7 (0.0, 3.7) | NS |
| Gender [females/males (%/%)] | 429/405 (51/49) | 212/171 (55/45) | NS | 461/409 (53/47) | 180/166 (52/48) | NS |
| IGF-I SDS | −1.7 (−3.7, −0.1) | −1.1 (−3.0, 0.2) | <0.001 | −1.8 (−3.7, −0.1) | −1.1 (−2.7, 0.3) | <0.001 |
| History of fracture [n (%)] | 200 (24) | 80 (21) | NS | 200 (23) | 79 (23) | NS |
| LS sBMD (mg/cm2) | 1028 (828, 1285) | 1055 (885, 1295) | <0.01 | 1032 (838, 1295) | 1038 (869, 1285) | NS |
| LS z score | −0.8 (−2.2, 1.3) | −0.3 (−1.8, 1.7) | <0.01 | −0.5 (−2.1, 1.5) | −0.3 (−1.9, 1.3) | NS |
| FN sBMD (mg/cm2) | 871 (691, 1063) | 883 (704, 1066) | NS | 878 (691, 1076) | 878 (700, 1057) | NS |
| FN z score | −0.4 (−1.7, 1.1) | 0 (−1.5, 1.2) | <0.01 | −0.3 (−1.7, 1.2) | −0.1 (−1.6, 1.1) | NS |
Data are shown as number of patients, percentages, mean ± sd, or median (10th and 90th percentiles) as appropriate. Def, Deficient; NS, not significant; suff, sufficient.