Table 2.
Clinical and pathological findings and levels of select adrenal steroids from APA and IHA patients after ACTH
| Case no. | Age (yr) | Sex | CT tumor size (mm) |
Localization of APA | Pre-ACTH |
Post-ACTH |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A (ng/dl) |
F (μg/dl) |
F (μg/dl) Ilv | F ratio |
A/F (%) |
A/F L-R | 18-oxoF (ng/dl) |
18-oxoF/F (%) |
18-oxoF/F L-R | |||||||||||||
| R | L | R | L | R | L | R/Ilv | L/Ilv | R | L | R | L | R | L | ||||||||
| APA (n = 14) | 1 | 35 | M | 8 | 18 | Lt | 266 | 8671 | 285 | 756 | 16 | 18.025 | 47.854 | 0.093 | 1.147 | 12.279 | 37 | 4813 | 0.013 | ||
| 2 | 38 | M | 23 | 10 | Rt | 8326 | 399 | 590 | 731 | 18 | 32.224 | 39.945 | 1.412 | 0.055 | 25.893 | 5291 | 229 | 0.897 | 0.031 | 28.617 | |
| 3 | 30 | M | n.d. | 11 | Lt | 496 | 13824 | 975 | 946 | 15 | 67.207 | 65.255 | 0.051 | 1.461 | 28.687 | 41 | 2847 | 0.004 | 0.301 | 71.511 | |
| 4 | 53 | M | n.d. | 18 | Lt | 227 | 8909 | 563 | 495 | 16 | 34.515 | 30.337 | 0.040 | 1.802 | 44.613 | 43 | 2623 | 0.008 | 0.531 | 70.063 | |
| 5 | 46 | M | n.d. | 19 | Lt | 194 | 9888 | 300 | 802 | 16 | 18.609 | 49.839 | 0.065 | 1.232 | 19.012 | 69 | 6837 | 0.023 | 0.852 | 36.998 | |
| 6 | 71 | M | n.d. | 14 | Lt | 559 | 7968 | 740 | 712 | 13 | 59.176 | 56.984 | 0.076 | 1.119 | 14.811 | 198 | 4229 | 0.027 | 0.594 | 22.134 | |
| 7 | 53 | F | 10 | n.d. | Rt | 3968 | 328 | 838 | 366 | 12 | 70.403 | 30.739 | 0.474 | 0.090 | 5.276 | 1699 | 117 | 0.203 | 0.032 | 6.340 | |
| 8 | 31 | F | n.d. | 12 | Lt | 550 | 9976 | 757 | 603 | 16 | 46.710 | 37.222 | 0.073 | 1.654 | 22.781 | 123 | 4652 | 0.016 | 0.771 | 47.306 | |
| 9 | 68 | F | 15 | n.d. | Rt | 23546 | 287 | 608 | 539 | 14 | 43.429 | 38.500 | 3.874 | 0.053 | 72.829 | 7652 | 143 | 1.259 | 0.027 | 47.371 | |
| 10 | 58 | M | n.d. | 20 | Lt | 423 | 5823 | 516 | 843 | 12 | 44.128 | 72.043 | 0.082 | 0.691 | 8.426 | 115 | 3454 | 0.022 | 0.410 | 18.459 | |
| 11 | 65 | M | 22 | n.d. | Rt | 2431 | 317 | 448 | 413 | 14 | 31.766 | 29.255 | 0.543 | 0.077 | 7.062 | 2128 | 115 | 0.475 | 0.028 | 17.100 | |
| 12 | 70 | M | n.d. | 16 | Lt | 359 | 15000 | 656 | 728 | 14 | 45.542 | 50.576 | 0.055 | 2.060 | 37.634 | 54 | 1924 | 0.008 | 0.264 | 31.850 | |
| 13 | 34 | F | n.d. | 30 | Lt | 260 | 7645 | 249 | 406 | 18 | 14.142 | 23.080 | 0.105 | 1.882 | 17.997 | 110 | 3552 | 0.044 | 0.875 | 19.717 | |
| 14 | 37 | F | 18 | n.d. | Rt | 9650 | 541 | 534 | 315 | 16 | 33.572 | 19.830 | 1.808 | 0.172 | 10.536 | 3440 | 91 | 0.645 | 0.029 | 22.430 | |
| IHA (n = 7) | 15 | 29 | M | n.d. | n.d. | 5053 | 5213 | 883 | 1126 | 13 | 67.954 | 86.631 | 0.572 | 0.463 | 1.236 | 462 | 364 | 0.052 | 0.032 | 1.620 | |
| 16 | 24 | M | n.d. | n.d. | 2955 | 1933 | 872 | 731 | 21 | 41.524 | 34.810 | 0.339 | 0.264 | 1.281 | 382 | 242 | 0.044 | 0.033 | 1.322 | ||
| 17 | 40 | M | n.d. | n.d. | 1807 | 2791 | 1090 | 1329 | 28 | 38.893 | 47.464 | 0.166 | 0.210 | 1.266 | 157 | 280 | 0.014 | 0.021 | 1.459 | ||
| 18 | 43 | M | n.d. | 14 | 4200 | 3111 | 866 | 788 | 27 | 32.074 | 29.185 | 0.485 | 0.395 | 1.229 | 462 | 184 | 0.053 | 0.023 | 2.284 | ||
| 19 | 43 | F | n.d. | n.d. | 7719 | 10470 | 1125 | 1083 | 13 | 87.891 | 84.578 | 0.686 | 0.967 | 1.410 | 1065 | 1249 | 0.095 | 0.115 | 1.219 | ||
| 20 | 43 | F | n.d. | n.d. | 4152 | 4663 | 371 | 437 | 18 | 20.396 | 23.989 | 1.118 | 1.068 | 1.047 | 537 | 535 | 0.145 | 0.122 | 1.181 | ||
| 21 | 35 | F | n.d. | n.d. | 3108 | 1984 | 867 | 639 | 15 | 59.807 | 44.041 | 0.358 | 0.311 | 1.153 | 586 | 141 | 0.068 | 0.022 | 3.063 | ||
A, Aldosterone; R, right adrenal vein; L, left adrenal vein; Ilv, iliac vein; n.d., not detectable; L-R, the ratio of L/R or R/L divided by the lower values; localization of APA, APA histopathologically detected in the right (Rt) or left (Lt) adrenal gland. The adrenal tumor in case 18 was histopathologically and immunohistochemically diagnosed as nonfunctional adrenal adenoma.