Table 3.
Total Daily Dosage of Metyrapone for Patients Treated With a Dose Titration Regimen
| Starting Dose (mg)a | Final Dose (mg)a | |
|---|---|---|
| Metyrapone monotherapy (n = 164) | 1040, 750, 250–3750 | 1425, 1500, 500–4000 |
| CD (n = 96) | 1020, 750, 250–3000 | 1380, 1375, 500–3500 |
| EAS (n = 27) | 1260, 1000, 500–3750 | 1990, 1500, 500–3750 |
| Benign adrenal disease (n = 31) | 820, 1000, 250–2250 | 1210, 750, 500–4000 |
| ACC (n = 10) | 1230, 1500, 750–2000 | 1190, 1250, 750–1500 |
| Presurgery (n = 124) | 1000, 750, 500–2250 | 1440, 1500, 500–4000 |
| CD (n = 81) | 980, 750, 500–2250 | 1400, 1500, 500–3500 |
| EAS (n = 11) | 1200, 1500, 500–2000 | 2120, 2250, 500–3750 |
| Benign adrenal disease (n = 25) | 880, 750, 500–2250 | 1230, 1000, 500–4000 |
| ACC (n = 7) | 1250, 1500, 750–2000 | 1080, 1000, 750–1500 |
| Secondary treatment (n = 25) | 1300, 1125, 500–3000 | 1400, 1500, 500–2250 |
| Long-term treatment (>6 mo) (n = 38) | 940, 750, 500–3000 | 1560, 1500, 500–4000 |
a
Given in 2–4 divided doses; mean, median, range.