Fig. 1.

Pedigrees of the family study. Squares indicate male family members and circles female family members. Slashes indicate deceased persons and arrows indicate probands. Roman numerals to the left of the pedigree indicate the generation; numerals to the upper left of each symbol indicate the individual family member. For the ANGPTL3 genotype, the X denotes a stop codon. The columns under each symbol indicate, from top to bottom, age, the total cholesterol, triglycerides, LDL, and HDL-C concentration (millimoles per liter). The values are the means of measurements from multiple fasting lipid profiles.